CELEBREX
Celebrex is is a nonsteroidal anti-inflammatory drug
(NSAID) known as a COX-2.
It is a new prescription medicine designed to relieve the pain, treat the symptoms of
osteoarthritis, rheumatoid arthritis and menstrual discomfort.
By reducing pain, inflammation, and stiffness, Celebrex can help people do everyday functions such as walking and bending.
GENERIC CELEBREX functions the same way as Celebrex, but at a lower cost. To learn more about
generic Celebrex, please follow the information we have provided
below.
What is Celecoxib
Celebrex (celecoxib)
is chemically designated as 4-[5-(4-methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]
benzenesulfonamide and is a diaryl substituted pyrazole.
The empirical formula for celecoxib is C17H14F3N3O2S and
the molecular weight is 381.38. Celebrex oral capsules
contain 100 mg and 200 mg of celecoxib. The inactive
ingredients in Celebrex capsules include: croscarmellose
sodium, edible inks, gelatin, lactose monohydrate,
magnesium stearate, povidone, sodium lauryl sulfate and
titanium dioxide.
Food Effects: When Celebrex capsules were taken
with a high fat meal, peak plasma levels were delayed
for about 1 to 2 hours with an increase in total
absorption (AUC) of 10% to 20%. Coadministration of
celecoxib with an aluminum-and magnesium-containing
antacid resulted in a reduction in plasma celecoxib
concentrations with a decrease of 37% in Cmax and 10% in
A.C. Celecoxib capsules can be administered without
regard to the timing of meals.
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Mechanism of action
In the body, there are 2 enzymes that are called COX-1 and COX-2.
COX-1 helps regulate normal cell function in the stomach and blood. COX-2 plays a role in causing arthritis pain
and inflammation. Celebrex is the first arthritis product to target only the COX-2 enzyme.
Celebrex is a nonsteroidal anti-inflammatory drug that exhibits anti-inflammatory analgesic, and antipyretic
activities in animal models. The mechanism of action of Celebrex is believed to be due to inhibition of
prostaglandin synthesis, primarily via inhibition of cyclooxygenase-2 (COX-2) and at therapeutic concentrations
in humans, celecoxib does not inhibit the cyclooxygenase-1 (COX-1) isoenzyme.
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Contraindications of Celebrex
Since Celebrex and GENERIC CELEBREX can create physical dependence,
it is not recommended for patients with a tendency to drug abuse, a history of
drug dependence, or chronically using opioids. Additionally, anyone who has had an allergic-type reaction to either
celecoxib or any product containing an opioid medicine (like Tylenol with Codeine) should not take generic Celebrex.
generic Celebrex should not be given to patients who have demonstrated allergic-type reactions to sulfonamides.
generic Celebrex should not be given to patients who have experienced asthma,
urticaria, or allergic-type reactions after taking aspirin or other
NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients.
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Side effects
The most frequently reported side effects experienced with Celebrex or
GENERIC CELEBREX were constipation, nausea, dizziness, headache, somnolence, and vomiting. Patients should talk to their
doctors about any side effects they experience while taking generic Celebrex.
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Dosage and administration
You will get the best pain relief by following your doctor's instructions
and taking generic Celebrex as it was prescribed for you. Generic Celebrex may be taken with or without food.
You may find it easiest to take your generic Celebrex tablets at the same times every day. In any case, you should
not take more than the dose prescribed, and you should never take more than 2 tablets in a 4-hour period.
The lowest dose of Celebrex should be sought for each patient.
Osteoarthritis: For relief of the signs and symptoms of osteoarthritis the recommended oral dose is 200 mg
per day administered as a single dose or as 100 mg twice per day.
Rheumatoid arthritis: For relief of the signs and symptoms of rheumatoid arthritis the recommended oral
dose is 100 to 200 mg twice per day.
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